Referências Bibliográficas
Base de evidências utilizada para construção das recomendações de interação medicamentosa. Todas as interações são fundamentadas em artigos publicados em periódicos indexados, bulas oficiais (FDA/EMA) e guidelines de sociedades médicas. Total: 34 referências.
Guideline / Recomendação (3)
Lewis R, Brüggemann RJ, Padoin C, Maertens J, Bentley A, Gustin C, et al. Triazole antifungal agents and targeted cancer therapies in haematology: recommendations for clinical management. J Antimicrob Chemother. 2024;79(6):1203-1217.
Brüggemann RJ, Verheggen R, Boerrigter E, Stanzani M, Verweij PE, Blijlevens NMA, Lewis RE Management of drug–drug interactions of targeted therapies for haematological malignancies and triazole antifungal agents. Lancet Haematol. 2022;9(1):e58-e72.
Stemler J, Cornely OA Antifungal prophylaxis in acute myeloid leukemia treated with targeted therapy: a practical approach. HemaSphere. 2022;6(7):e741.
Consenso (1)
Chau MM, Kong DCM, van Hal SJ, Urbancic K, Trubiano JA, Slavin MA, Thursky KA Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy and haemopoietic stem cell transplant recipients, 2021. Intern Med J. 2021;51(Suppl 7):37-66.
Revisão (7)
Azanza JR, Mensa J, Barberán J, Vázquez L, Aguado JM Recommendations for the use of azole antifungals in haematology-oncology patients. Rev Esp Quimioter. 2023;36(2):157-179.
Salvatorelli E, Menna P, Minotti G Managing the adverse effects of midostaurin: focus on drug interactions. Chemotherapy. 2023;68(3):170-182.
Megías-Vericat JE, Solana-Altabella A, Ballesta-López O, et al. Drug-drug interactions of newly approved small molecule inhibitors for acute myeloid leukemia. Ann Hematol. 2022;101:1805-1818.
Groll AH, Townsend R, Desai A, Azie N, Jones ME, Engelhardt M, et al. Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4. Transpl Infect Dis. 2017;19(5):e12751.
Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Bentata L Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Cancer Treat Rev. 2011;37(4):290-303.
Dodds-Ashley E Management of drug and food interactions with azole antifungal agents in transplant recipients. Pharmacotherapy. 2010;30(8):842-854.
Brüggemann RJ, Alffenaar JW, Blijlevens NM, et al. Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents. Clin Infect Dis. 2009;48(10):1441-1458.
Estudo Clínico (13)
Hayashi H, Yamagiwa T, Kanda J, et al. Impact of venetoclax trough levels on safety and efficacy in the treatment of acute myeloid leukemia. Sci Rep. 2026.
Sciumè M, Bosi A, Canzi M, et al. Real-life monocentric experience of venetoclax-based regimens for acute myeloid leukemia. Hematol Oncol. 2024.
Fructuoso-González L, Gutiérrez-Gutiérrez B, Rodríguez-Benítez P, et al. Isavuconazole-tacrolimus interaction in kidney transplant recipients. J Antimicrob Chemother. 2023;78(10):2559-2562.
DiNardo CD, Jonas BA, Pullarkat V, et al. Azacitidine and venetoclax in previously untreated acute myeloid leukemia (VIALE-A). N Engl J Med. 2020;383(7):617-629.
Tam CS, Trotman J, Opat S, et al. Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL. Blood. 2020;136(18):2038-2050.
Schlenk RF, Weber D, Fiedler W, et al. Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD (RATIFY post-hoc analysis). Leukemia. 2019;33(10):2420-2428.
Aldoss I, Dadwal S, Zhang J, et al. Invasive fungal infections in acute myeloid leukemia treated with venetoclax and hypomethylating agents. Leuk Lymphoma. 2019;60(11):2820-2822.
Girmenia C, Iori AP Safety of interaction of echinocandins with cyclosporine and tacrolimus in hematopoietic stem cell transplant recipients. Expert Opin Drug Saf. 2017;16(3):329-339.
Moriyama B, Henning SA, Leung J, et al. Adverse interactions between antifungal azoles and vincristine: review and analysis of cases. Clin Infect Dis. 2012;54(12):1753-1767.
Kubiak DW, Koo S, Hammer MM, et al. A prospective study of posaconazole-sirolimus drug interaction in allogeneic hematopoietic stem cell transplant recipients. Antimicrob Agents Chemother. 2012;56(6):3468-3472.
Sánchez-Ortega I, Patiño B, Arnan M, et al. Clinical efficacy and safety of posaconazole prophylaxis in allogeneic hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant. 2012;18(5):759-767.
Saad AH, DePestel DD, Carver PL Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants. Clin Infect Dis. 2006;43(5):e36-e38.
Venkataramanan R, Zang S, Gayowski T, Singh N Voriconazole inhibition of the metabolism of tacrolimus in a liver transplant recipient and in human liver microsomes. Antimicrob Agents Chemother. 2002;46(9):3091-3093.
Farmacocinética / PK (10)
Tian DD, Guo P, Engel SS, et al. Physiologically based pharmacokinetic modeling of pirtobrutinib to predict drug-drug interactions. CPT Pharmacometrics Syst Pharmacol. 2025;14(12):2221-2231.
Yang J, Wang H, Liu D, et al. A population pharmacokinetics study of venetoclax concomitant with voriconazole in patients with hematologic malignancies. Drug Des Dev Ther. 2025;19:3681-3690.
Flanagan S, Goodman DB, Engel S, et al. Lack of clinically relevant drug-drug interactions between rezafungin and common concomitant medications. Antimicrob Agents Chemother. 2023;67(6):e01339-23.
Zhou D, Podoll T, Engel J, et al. Evaluation of the drug-drug interaction potential of acalabrutinib and its active metabolite, ACP-5862, using a physiologically based pharmacokinetic modeling approach. J Clin Pharmacol. 2020;60(10):1306-1318.
James AJ, Smith CC, Litzow M, et al. Pharmacokinetic profile of gilteritinib: a novel FLT3 tyrosine kinase inhibitor. J Clin Pharmacol. 2020;60(S2):S73-S84.
Agarwal S, Salem AH, Danilov AV, et al. Effect of ketoconazole, a strong CYP3A inhibitor, on the pharmacokinetics of venetoclax, a BCL-2 inhibitor, in patients with non-Hodgkin lymphoma. Clin Pharmacol Ther. 2017;101(S1):S80.
Lempers VJ, van den Heuvel JJ, Russel FG, Aarnoutse RE, Burger DM, Brüggemann RJ, Koenderink JB Inhibitory potential of antifungal drugs on ATP-binding cassette transporters P-glycoprotein, MRP1 to MRP5, BCRP, and BSEP. Curr Opin Pharmacol. 2015;24:38-44.
de Jong J, Sukbuntherng J, Skee D, et al. The effect of CYP3A perpetrators on ibrutinib exposure in healthy participants. Cancer Chemother Pharmacol. 2015;75(5):1007-1017.
Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers. Cancer Chemother Pharmacol. 2013;72(6):1223-1234.
Shi JG, Chen X, McGee RF, et al. The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers. J Clin Pharmacol. 2012;52(11):1603-1612.
Bulas Oficiais (Prescribing Information)
Além dos artigos acima, as seguintes bulas oficiais (FDA/EMA) foram consultadas para recomendações de ajuste de dose:
Como Citar Esta Ferramenta
Morales HMP. InfectoSmart Drug Interaction Checker: Interações entre terapias hematológicas e antifúngicos [ferramenta online]. Versão 2.2. Março 2026. Disponível em: [URL].